Shaun Murphy, a young autistic surgeon who has savant syndrome, relocates from a quiet country life to join the surgical unit at the prestigious San Jose St. Bonaventure Hospital. Having survived a troubled childhood, Shaun is alone in the world and unable to personally connect with those around him, but he finds his niche using his extraordinary medical skill and intuition to save lives and challenge the skepticism of his colleagues.

The teenagers of Disney's most infamous villains return to the Isle of the Lost to recruit a new batch of villainous offspring to join them at Auradon Prep. Mal and her friends face their biggest challenge yet when an unfathomable dark force threatens the people of Auradon.