Shaun Murphy, a young autistic surgeon who has savant syndrome, relocates from a quiet country life to join the surgical unit at the prestigious San Jose St. Bonaventure Hospital. Having survived a troubled childhood, Shaun is alone in the world and unable to personally connect with those around him, but he finds his niche using his extraordinary medical skill and intuition to save lives and challenge the skepticism of his colleagues.
In 2033, humans are able to "upload" themselves into a virtual afterlife of their choosing. When computer programmer Nathan dies prematurely, he is uploaded to the very expensive Lake View, but soon finds himself under the thumb of his possessive, still-living girlfriend Ingrid. As Nathan adjusts to the pros and cons of digital heaven, he bonds with Nora, his living customer service rep, or "Angel".