The story of Tully and Kate, two unlikely friends from their meeting as tweens in 1974 to the present. Kate, the introvert, and Tully, the coolest girl in school, form a bond that weathers every milestone in their lives, leading up to a tragedy in the present.

In 2033, humans are able to "upload" themselves into a virtual afterlife of their choosing. When computer programmer Nathan dies prematurely, he is uploaded to the very expensive Lake View, but soon finds himself under the thumb of his possessive, still-living girlfriend Ingrid. As Nathan adjusts to the pros and cons of digital heaven, he bonds with Nora, his living customer service rep, or "Angel".